Improved immunisation programmes and the development of new vaccines provide unprecedented opportunities to improve and sustain the health of our children. There are major challenges ahead in communicating the benefits of immunisation to all populations and in delivering vaccines to those in greatest need. In this review on immunisation, I have asked international opinion leaders [...]

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Abstract Carcinoembryonic antigen (CEACAM5) is commonly overexpressed in human colon cancer. Several antigenic peptides recognized by cytolytic CD8+ T-cells have been identified and used in colon cancer phase-I vaccination clinical trials.
The HLA-A*0201-binding CEA694�702 peptide was recently isolated from acid eluted MHC-I associated peptides from a human colon tumor cell line. However, the
immunogenicity of this [...]

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Background:
In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of human melanoma cells rendered apoptotic/necrotic by gamma irradiation (Apo-Nec cells).
Methods:
We evaluated the phagocytosis of Apo-Nec cells by FACS after PKH26 and PKH67 staining of DCs and Apo-Nec cells [...]

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Objective. Persons who receive live attenuated vaccine may occasionally transmit the vaccine strain to others. The risk of such transmission is a concern, especially for persons who provide care to immunocompromised patients (ie, family and healthcare workers [HCWs]).
Since the Advisory Committee on Immunization Practices released guidelines 10 years ago, several new live attenuated products [...]

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Comparison of an ESAT-6/CFP-10 Peptide-Based ELISPOT Assay to Tuberculin Skin Test for Tuberculosis Screening in a Moderate Risk Population.
Clin Vaccine Immunol. 2007 Apr 18;
Authors: Porsa E, Cheng L, Graviss EA
BACKGROUD: Screening for latent tuberculosis infection (LTBI) with Mantoux tuberculin skin test (TST) has many limitations including false positive results due to Bacille [...]

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